Some individuals with PNES may have confusion or loss of consciousness without shaking or a feeling of being “disassociated” (or somewhat disconnected) from thoughts or feelings or from the environment. There may be episodes of movement, sensation, and behavior similar to an epileptic seizure and a temporary loss of attention or memory lapse. Psychogenic nonepileptic seizures (PNES) may look like generalized or other forms of epileptic seizures but are caused by brain dysfunction and not by abnormal electrical signaling in the brain. FND sometimes may result from a somatic symptoms disorder (characterized predominantly by multi-system symptoms that are associated with distress and/or dysfunction and look like a physical illness). Fundamental causes may involve biological factors (such as early childhood trauma and early life stress, emotions,anxiety, witness to violence, maltreatment, or childhood sexual abuse) or sociological factors (including interpersonal relationships and stress). An estimated 4 to 12 people per 100,000 will develop FND. FND can involve any part of the body.Īnyone can develop FND but it is more common in women. Memory, concentration, cognition, and the processing of sensations also can be affected.
Someone with FND can function normally, they just can’t at that moment. There is no structural damage the brain is unable to send and receive signals properly and there is a disconnection in the function of the lobes and emotional processing. You can also indicate country and state to find trials near you.įunctional neurologic disorder (FND), also called conversion disorder and functional neurologic symptom disorder, refers to a group of common neurological movement disorders caused by an abnormality in how the brain functions. Enter “functional neurological disorder” into the “Condition or disease” field to identify current and past trials. Among other research, investigators hope to better treat PNES and to test medications for PNES.Ĭlinical research on FND can be found at, a database of thousands of research studies in the U.S. Scientists funded by the NIH are working to better understand the underlying neuropathology of FND and hope to develop neuroimaging biomarkers-signs that may indicate risk of developing a disease or be used to monitor its progression-for FND and nonepileptic seizures. Among NINDS research, scientists are studying the neurobiology of FND and nonepileptic seizures, as well as any clinical association of the effects of the COVID-19 pandemic on individuals with functional movement disorder. Several research projects on FND are funded by the National Institutes of Health (NIH, the leading supporter of biomedical research in the world) and its National Institute of Neurological Disorders and Stroke (NINDS, the leading federal funder of research on the brain and nervous system).
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